![]() ![]() ![]() Are antibiotics scheduled and dosed optimally?.If no clear infection, consider sepsis mimics.Is further investigation needed to identify the source? □.#2/2: secondary survey correct diagnosis? DVT prophylaxis with low molecular weight heparin (if GFR >30 ml/min) or otherwise unfractionated heparin.Hydrocortisone 50 mg IV q6hr, unless contraindicated.Early peripheral vasopressors to maintain MAP >65.Other drainage/debridement (e.g., decompress hydronephrosis, ERCP for cholangitis, abscess drainage).Consider hardware removal (e.g., port, tunneled line, central line).difficile: oral vancomycin +/- IV metronidazole. Possible tick-borne illness: Doxycycline.Community-acquired pneumonia: Azithromycin or doxycycline.Consider additional antibiotics depending on source, e.g.:.Consider selectively adding MRSA coverage if there is a soft tissue infection, line infection, nosocomial infection, or for selected pneumonia patients.Start with a solid beta-lactam backbone (e.g., piperacillin-tazobactam □, meropenem □, or cefepime □).Review prior cultures & antibiotic exposure data (if available).Additional tests as warranted (more on source evaluation: □).Consider CT abdomen/pelvis if no definite source (especially in obtunded/elderly patients).If not definitively sepsis: procalcitonin (+/- CRP in renal failure).Peripheral blood culture x2, culture of any line in place >48 hours.#1/2: initial resuscitation investigations ![]()
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